Cytotoxicity and Cell Growth Status on Ag+-Implanted Pyrolytic Carbon and TiN/Ag Multilayer Films
J. Korean Phy. Soc. 2008; 52: 46~49
Published online February 20, 2008 © 2008 The Korean Physical Society.

Abstract
Ag$^{+}$-implanted pyrolytic carbon and TiN/Ag multilayer films were prepared by ion implantation and ion beam assisted deposition. L-929 cells (mice fibroblast) were cultured in the extracted medium of Ag$^{+}$-implanted pyrolytic carbon and TiN/Ag multilayer film samples for cytotoxicity testing. The adhesion, spreading, proliferation and morphology of human umbilical vein endothelial cells (HUVEC) on both samples were also investigated. The results show that the cytotoxicity grade of Ag$^{+}$-implanted pyrolytic carbon is less than 1$^{circ}$ when the implanted dose is under $1 imes 10^{16}$ ions/cm$^2$ and the cytotoxicity grade of TiN/Ag multilayer films with modulation period of 7.5 nm is within the range of 0 to 1$^{circ}$ indicating that both samples have no cytotoxicity to L-929. HUVEC on both Ag$^+$-implanted pyrolytic carbon and TiN/Ag multilayer film sample grows well, showing that they have good biocompatibility.
Keywords: Ion implantation, Ion beam assisted deposition (IBAD), Cytotoxicity, Human umbilical vein endothelial cells (HUVEC)


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