Essentiality Landscape of Metabolic Networks
J. Korean Phy. Soc. 2019; 74: 512~521
Published online March 15, 2019 © 2019 The Korean Physical Society.


1 SS, CTP and Department of Physics and Astronomy, Seoul National University, Seoul 08826, Korea
2 Department of Economics, University of Michigan, Ann Arbor, Michigan 48109, USA
3 Department of Physics, Inha University, Incheon 22212, Korea
Correspondence to: B. Kahng, D.-S. Lee
Abstract
The essentiality of metabolic reactions is estimated for hundreds of species by the flux balance analysis for the growth rate after removal of individual and pairs of reactions. About 10% of reactions are essential, i.e., growth stops without them. This large-scale and cross-species study allows us to determine ad hoc ages of each reaction and species. We find that when a reaction is older and in younger species, the reaction is more likely to be essential. Such correlations may be attributable to the recruitment of alternative pathways during evolution to ensure the stability of important reactions.
PACS numbers: 87.16.A-
Keywords: Metabolic network, Flux balance analysis (FBA)


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